LOGO 2013 3   


News - Announcements

gene-sResearchers from the RIKEN Center for Integrative Medical Sciences in Japan have identified the first gene to be associated with adolescent idiopathic scoliosis (also called AIS) across Asian and Caucasian populations. The gene is involved in the growth and development of the spine during childhood.

Their study is published today in the journal Nature Genetics.

AIS is the most common pediatric skeletal disease, affecting approximately 2% of school-age children. The causes of scoliosis remain largely unknown and brace treatment and surgery are the only treatment options. However, many clinical and genetic studies suggest a contribution of genetic factors.

To understand the causes and development of scoliosis, Dr Ikuyo Kou, Dr Shiro Ikegawa and their team have tried to identify genes that are associated with a susceptibility to develop the condition.

By studying the genome of 1,819 Japanese individuals suffering from scoliosis and comparing it to 25,939 Japanese individuals, the team identified a gene associated with a susceptibility to develop scoliosis on chromosome 6. The association was replicated in Han Chinese and Caucasian populations.gn an

The researchers show that the susceptibility gene, GPR126, is highly expressed in cartilage and that suppression of this gene leads to delayed growth and bone tissue formation in the developing spine. GPR126 is also known to play a role in human height and trunk length.

"Our finding suggest the interesting possibility that GPR126 may affect both AIS susceptibility and height through abnormal spinal development and growth," explain the authors.

"Further functional studies are necessary to elucidate how alterations in GPR126 increase the risk of AIS in humans," they conclude.

SOSORT PhotoOn May 8-11, 2013was heldin Chicago the annual SOSORT (International Society on Scoliosis Orthopedic Rehabilitation and Treatment) conference,wherethe Scientific Director of SPONDYLOS Laser Spine Lab,Dr.DimitrisPapadopoulos, first announced,the results from theconservativeTreatmentinAdultscoliosis.The workwasvery well receivedby the scientific communityand will soon bepublishedin the officialjournalSCOLIOSIS.

This is anothersuccessfuleffort of SPONDYLOS Laser Spine Labin the clinical researchof diseases ofthe spine.




Adult scoliosis treatment



Innovating once again SPONDYLOS, introduces the combination of surface topography and foot pressure analysis in daily practice.

formetric4D pedoscan 300x300px

formetric pedo software

By combining the two measurement systems DIERS Formetric 4D and DIERS Pedoscan may also be considered spine, pelvic position, the pressure conditions under foot and the center of gravity of the body.

This synchronized measurement is a valuable tool for an optimal treatment eg correction of posture with corrective insoles, and control of lumbar scoliosis.


In most cases the orthopaedic surgeon comes in dilemma on how to plan a treatment of an Adolescent Idiopathic Scoliosis, which is small (10 ° - 25 ° angle Cobb), in a child aged 9-13 years. Usually the child comes to monitoring and waits for possible aggravation. In other cases, the child begins treatment with a brace and / or exercises. In all cases there is no certainty about the decision, and all is based on the experience of the physician. In the first case loss of valuable time for treatment, in the latter may not need such intense treatment.

The ScoliScore is the latest weapon in the arsenal of the orthopedic surgeon for planning the treatment of Adolescent Idiopathic Scoliosis

 ScoliscorekitIt is collected saliva from the child and sent it to the laboratory of ScoliScore in USA, which analyzes the DNA. After 3 weeks, the result is sent to the orthopedic surgeon with a calibration of 1-200. The lower the rank, the less risk there is to worsening the scoliosis. The negative results have a validity of 99%.The results of ScoliScore with other clinical factors of scoliosis such as Cobb angle start of menstrual periods, bone age, height increase, etc. will be used by the orthopedic surgeon to design a personalized and effective treatment.